David A. McDonald

Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations

Robert Shenkar, Changbin Shi, Tania Rebeiz et al. · Genetics in Medicine · 2014 · 165 citations · Full text

Medicine, Molecular Genetics, Neuroscience +14

Fasudil Decreases Lesion Burden in a Murine Model of Cerebral Cavernous Malformation Disease

David A. McDonald, Changbin Shi, Robert Shenkar et al. · Stroke · 2011 · 148 citations · Full text

Life Sciences, Neurobiology, Neuroscience +16

Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis

David A. McDonald, Changbin Shi, Robert Shenkar et al. · Human Molecular Genetics · 2014 · 139 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease

David A. McDonald, Robert Shenkar, Changbin Shi et al. · Human Molecular Genetics · 2010 · 133 citations · Full text

Life Sciences, Genetics, Neurology +16

RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations

Robert Shenkar, Changbin Shi, Cecilia Austin et al. · Stroke · 2016 · 105 citations · Full text

Life Sciences, Neuroscience, Pharmacology +10