Biologically Active Oligodeoxyribonucleotides. 5. 5‘-End-Substituted d(TGGGAG) Possesses Anti-Human Immunodeficiency Virus Type 1 Activity by Forming a G-Quadruplex Structure

Hitoshi Hotoda, Makoto Koizumi, Rika Koga, +12

Journal of Medicinal Chemistry

Bioorganic ChemistryMolecular BiologyBenzyl GroupAntiviral DrugChemical Biology +16

Activity of capuramycin analogues against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium intracellularein vitro and in vivo

Tetsufumi Koga, Takashi Fukuoka, Norio Doi, +8

Journal of Antimicrobial Chemotherapy

Synthesis and antimycobacterial activity of capuramycin analogues. Part 1: substitution of the azepan-2-one moiety of capuramycin

Hitoshi Hotoda, Miyuki Furukawa, Makiko Daigo, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ChemistryAzepan-2-one MoietyMedicineAntibacterial Agent +7

Molecular Recognition of Adenophostin, a Very Potent Ca²⁺ Inducer, at the <scp>d</scp>-<i>myo</i>-Inositol 1,4,5-Trisphosphate Receptor

Hitoshi Hotoda, Kazuhiro Murayama, Shuichi Miyamoto, +5

Biochemistry

Molecular BiologyRecognition ModePutative Binding SiteCellular PhysiologyMolecular Pharmacology +18

Synthesis and antimycobacterial activity of capuramycin analogues. Part 2: acylated derivatives of capuramycin-related compounds

Hitoshi Hotoda, Makiko Daigo, Miyuki Furukawa, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ChemistryBioorganic ChemistryDerivativesNatural Sciences +8

Biologically active oligodeoxyribonucleotides—IX.1 Synthesis and anti-HIV-1 activity of hexadeoxyribonucleotides, TGGGAG, bearing 3′- and 5′-end-modification

Makoto Koizumi, Rika Koga, Hitoshi Hotoda, +12

Bioorganic & Medicinal Chemistry

Nucleic Acid ChemistryBioorganic ChemistryBiochemistryNatural SciencesHuman Retrovirus +9

IP3 receptor-ligand. 1: Synthesis of adenophostin A

Hitoshi Hotoda, Masaaki Takahashi, Kazuhiko Tanzawa, +2

Tetrahedron Letters

Molecular PharmacologySignal TransductionBiochemistryG Protein-coupled ReceptorFunctional Selectivity +3

Biologically Active Oligodeoxyribonucleotides - II¹: Structure Activity Relationships of Anti-HIV-1 Pentadecadeoxyribonucleotides Bearing 5′-End-Modifications

Hitoshi Hotoda, Kenji Momota, Hidehiko Furukawa, +4

Nucleosides and Nucleotides

Molecular BiologyPeptide ScienceAntiviral DrugActive OligodeoxyribonucleotidesMolecular Pharmacology +19

A new class of condensing reagents for rapid internucleotide bond formation in the phosphotriester approach and preparation of n3-benzoylthymidine as a key intermediate in oligodeoxyribonucleotide synthesis

Junichi Matsuzaki, Hitoshi Hotoda, Mitsuo Sekine, +1

Tetrahedron Letters

Bioorganic ChemistryKey IntermediateBiochemistryNatural SciencesOligonucleotide +5

Postmarketing safety experience with edoxaban in Japan for thromboprophylaxis following major orthopedic surgery

Yasufumi Kuroda, Chie Hirayama, Hitoshi Hotoda, +2

Vascular Health and Risk Management