ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

Víctor A. Arrieta, Andrew Chen, J. Robert Kane, +39

Nature Cancer

Neuro-oncologyGliomaErk1/2 PhosphorylationMedicinePathology +6

AID-Driven Deletion Causes Immunoglobulin Heavy Chain Locus Suicide Recombination in B Cells

Sophie Péron, Brice Laffleur, Nicolas Denis-Lagache, +6

Science

Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry

Junghyun Lim, Pankaj K. Giri, David Kazadi, +15

Cell

ChromatinGenome InstabilityTranscriptional RegulationChromatin StructureChromatin Remodeling +10

Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells

Brice Laffleur, Junghyun Lim, Wanwei Zhang, +8

Nature Genetics

ChromatinSomatic HypermutationGeneticsRna BiologyB Cells +7

Self-Restrained B Cells Arise following Membrane IgE Expression

Brice Laffleur, Sophie Duchez, Karin Tarte, +5

Cell Reports

The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity

Alexander Rialdi, Judd F. Hultquist, David Jimenez‐Morales, +21

Cell

Viral ReplicationMolecular VirologyPathogenesisVirologyViral Ribogenesis +6

Fam72a enforces error-prone DNA repair during antibody diversification

Mélanie Rogier, Jacques Moritz, Isabelle Robert, +16

Nature

Genome InstabilityImmunologyAntibody EngineeringAntibody ScreeningMedicine +2

Mechanism of noncoding RNA-associated N6-methyladenosine recognition by an RNA processing complex during IgH DNA recombination

Lekha Nair, Wanwei Zhang, Brice Laffleur, +12

Molecular Cell

ChromatinNatural SciencesGeneticsIgh Dna RecombinationRna Biology +8

Anti-CD20 IgA can protect mice against lymphoma development: evaluation of the direct impact of IgA and cytotoxic effector recruitment on CD20 target cells

Virginie Pascal, Brice Laffleur, Arnaud Debin, +8

Haematologica

Noncoding RNA transcription alters chromosomal topology to promote isotype-specific class switch recombination

Gerson Rothschild, Wanwei Zhang, Junghyun Lim, +11

Science Immunology