Michael J. Castle

Dosage Thresholds for AAV2 and AAV8 Photoreceptor Gene Therapy in Monkey

Luk H. Vandenberghe, Peter Bell, Albert M. Maguire et al. · Science Translational Medicine · 2011 · 224 citations

Adeno-Associated Virus Serotypes 1, 8, and 9 Share Conserved Mechanisms for Anterograde and Retrograde Axonal Transport

Michael J. Castle, Zachary T. Gershenson, April R. Giles et al. · Human Gene Therapy · 2014 · 153 citations · Full text

Serotype 8, Viral Replication, Molecular Biology +20

Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids

Michael J. Castle, Heikki Turunen, Luk H. Vandenberghe et al. · Methods in molecular biology · 2015 · 147 citations · Full text

Engineered Capsids, Aav Tropism, Neurovirology +7

Postmortem Analysis in a Clinical Trial of AAV2-NGF Gene Therapy for Alzheimer's Disease Identifies a Need for Improved Vector Delivery

Michael J. Castle, Fernando C. Baltanás, Imre Kovács et al. · Human Gene Therapy · 2020 · 115 citations · Full text

Long-distance Axonal Transport of AAV9 Is Driven by Dynein and Kinesin-2 and Is Trafficked in a Highly Motile Rab7-positive Compartment

Michael J. Castle, Eran Perlson, Erika L.F. Holzbaur et al. · Molecular Therapy · 2013 · 90 citations · Full text