The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

Kui Ming Chan, Fang Dong, Haiyun Gan, +9

Genes & Development

Genomic instability in laminopathy-based premature aging

Baohua Liu, Jianming Wang, Kui Ming Chan, +18

Nature Medicine

Lifespan ExtensionAgingLongevityGeneticsDegenerative Disease +2

Impaired Angiogenesis, Delayed Wound Healing and Retarded Tumor Growth in Perlecan Heparan Sulfate-Deficient Mice

Zhongjun Zhou, Jian Ming Wang, Renhai Cao, +6

Cancer Research

Ruminococcus gnavus plays a pathogenic role in diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis

Lixiang Zhai, Chun‐Hua Huang, Ziwan Ning, +18

Cell Host & Microbe

Functional Gastrointestinal DisorderRuminococcus GnavusSerotonin BiosynthesisPathogenic RolePathogenesis +7

Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling

Hao Huang, Jianyang Hu, Alishba Maryam, +14

Nature Communications

CRISPR-assisted detection of RNA–protein interactions in living cells

Wenkai Yi, Jingyu Li, Xiaoxuan Zhu, +12

Nature Methods

Gene EditingGenome EditingCrispr-assisted DetectionGene ExpressionMedicine +2

MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis

Kui Ming Chan, Hoi Leong Xavier Wong, Guoxiang Jin, +6

Developmental Cell

MechanobiologyDevelopmental BiologyBone Morphogenic ProteinOsteoporosisMatrix Biology +5

TLR ligand–induced podosome disassembly in dendritic cells is ADAM17 dependent

Michele West, Alan R. Prescott, Kui Ming Chan, +4

The Journal of Cell Biology

ImmunologyToll-like ReceptorExtracellular MicrovesiclesCytoskeletonInnate Immunity +17

RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair

Liwei An, Chao Dong, Junshi Li, +6

Proceedings of the National Academy of Sciences

A lesson learned from the H3.3K27M mutation found in pediatric glioma

Kui Ming Chan, Jing Han, Fang Dong, +2

Cell Cycle