Dirk Schumacher

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

Moritz Schütte, Thomas S. Risch, Nilofar Abdavi-Azar et al. · Nature Communications · 2017 · 349 citations · Full text

Medicine, Molecular Medicine, Oncology +17

Network quantification of EGFR signaling unveils potential for targeted combination therapy

Bertram Klinger, Anja Sieber, Raphaela Fritsche‐Guenther et al. · Molecular Systems Biology · 2013 · 175 citations · Full text

Medicine, Oncology, Pharmacology +17

Assay Establishment and Validation of a High-Throughput Screening Platform for Three-Dimensional Patient-Derived Colon Cancer Organoid Cultures

Karsten Boehnke, Philip W. Iversen, Dirk Schumacher et al. · SLAS DISCOVERY · 2016 · 151 citations · Full text

Medicine, Cell Biology, Oncology +17

Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells

Joseph L. Regan, Dirk Schumacher, Stephanie Staudte et al. · Cell Reports · 2017 · 135 citations · Full text

Life Sciences, Cell Biology, Oncology +17

DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer

Soulafa Mamlouk, Liam Childs, Daniela E. Aust et al. · Nature Communications · 2017 · 131 citations · Full text

Medicine, Genetics, Oncology +17