α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II

Lan‐Feng Dong, Philip S. Low, Jeffrey C. Dyason, +14

Oncogene

Mitochondrial FunctionBiochemistryMedicineMitochondrial DynamicApoptosis +5

Suppression of Tumor Growth<i>In vivo</i>by the Mitocan α-tocopheryl Succinate Requires Respiratory Complex II

Lan‐Feng Dong, Ruth Freeman, Ji Liu, +13

Clinical Cancer Research

Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy

Lan‐Feng Dong, Victoria J.A. Jameson, David Tilly, +22

Free Radical Biology and Medicine

α-Tocopheryl SuccinateMitochondrial FunctionEffective Cancer TherapyMedicinePharmacology +9

Hippo/Mst1 Stimulates Transcription of the Proapoptotic Mediator <i>NOXA</i> in a FoxO1-Dependent Manner

Karel Vališ, Lubomír Procházka, Evžen Bouřa, +6

Cancer Research

α-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels

Lubomír Procházka, Lan‐Feng Dong, Karel Vališ, +3

APOPTOSIS

BiologyMembrane Fusionα-Tocopheryl SuccinateMolecular PhysiologyBiochemistry +13

Pharmacological inhibition of fatty-acid oxidation synergistically enhances the effect of l-asparaginase in childhood ALL cells

Ivana Heřmanová, Amaia Arruabarrena-Aristorena, Karel Vališ, +15

Leukemia

BiochemistryChildhood All CellsMedicineFatty-acid OxidationPharmacological Inhibition +4

Shikonin regulates C-MYC and GLUT1 expression through the MST1-YAP1-TEAD1 axis

Karel Vališ, Pavel Talacko, Valéria Grobárová, +2

Experimental Cell Research

Glut1 ExpressionSignal TransductionProtein FunctionSignaling PathwayCell Regulation +7

VDAC2 and aldolase A identified as membrane proteins of K562 cells with increased expression under iron deprivation

Karel Vališ, Jitka Neubauerová, Petr Man, +3

Molecular and Cellular Biochemistry

Reductive StressCell PhysiologyAldo-keto ReductaseBiochemistryHeme Homeostasis +12

MS-Based Approaches Enable the Structural Characterization of Transcription Factor/DNA Response Element Complex

Lukáš Slavata, Josef Chmelı́k, Daniel Kavan, +11

Biomolecules

Structural CharacterizationProtein AssemblyStructural BioinformaticsGeneticsDna Response +20

Quambalarine B, a Secondary Metabolite from<i>Quambalaria cyanescens</i>with Potential Anticancer Properties

Valéria Grobárová, Karel Vališ, Pavel Talacko, +7

Journal of Natural Products