Suppression of Tumor Growth<i>In vivo</i>by the Mitocan α-tocopheryl Succinate Requires Respiratory Complex II

Abstract

We document in this report a novel paradigm, according to which the mitochondrial CII, which rarely mutates in human neoplasias, is a plausible target for anticancer drugs from the group of vitamin E analogues, providing support for their testing in clinical trials.