BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

William Farnaby, Manfred Koegl, Michael J. Roy, +34

Nature Chemical Biology

Tumor BiologyMedicineNatural SciencesMolecular BiologyCancer Genomics +8

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

Laetitia J. Martin, Manfred Koegl, Gerd Bader, +23

Journal of Medicinal Chemistry

Molecular BiologyCancer BiologyTumor BiologyIndividual SubunitsStructure-based Design +15

Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells

Gerard Brady, Filio Billia, Jennifer J. Knox, +10

Current Biology

Functional GenomicsDevelopmental BiologySingle Cell SequencingMedicineComplex Differentiation Hierarchy +6

BacPROTACs mediate targeted protein degradation in bacteria

Francesca Morreale, Stefan Kleine, Julia Leodolter, +19

Cell

Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells

Guido Boehmelt, Andrew Wakeham, Andrew Elia, +9

The EMBO Journal

Cell RegulationMedicineCell ProliferationEmeg32-deficient CellsCancer Biology +3

Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1

Anastasia Blagoveshchenskaya, Fei Ying Cheong, Holger M. Rohde, +5

The Journal of Cell Biology

Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers

Sandra Schick, André F. Rendeiro, Kathrin Runggatscher, +14

Nature Genetics

Systematic CharacterizationIntracomplex Synthetic LethalitiesSomatic VariantOncogenic AgentMedicine +8

Tumor cell‐specific inhibition of <scp>MYC</scp> function using small molecule inhibitors of the <scp>HUWE</scp> 1 ubiquitin ligase

Stefanie Peter, Jennyfer Bultinck, Kevin Myant, +14

EMBO Molecular Medicine

Discovery of Novel Spiro[3<i>H</i>-indole-3,2′-pyrrolidin]-2(1<i>H</i>)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction

Andreas Gollner, Dorothea Rudolph, Heribert Arnhof, +18

Journal of Medicinal Chemistry

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3

Jark Böttcher, David Dilworth, Ulrich Reiser, +40

Nature Chemical Biology

Chemical BiologyMolecular CharacterizationBiochemistryNatural SciencesMolecular Biology +7