Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling.

Yuji Yamanashi, Masato Okada, Takashi Semba, +7

Proceedings of the National Academy of Sciences

ImmunologyAntigen ProcessingHs1 GeneSignaling PathwayCell Regulation +14

Tumor necrosis factor-alpha induces expression of monocyte chemoattractant JE via fos and jun genes in clonal osteoblastic MC3T3-E1 cells

Shigemasa Hanazawa, Akira Takeshita, Shigeru Amano, +4

Journal of Biological Chemistry

InflammationJun GenesJe Gene ExpressionJe Gene ProductCytokine +13

Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells

Shogo Okazaki, Subaru Shintani, Yuki Hirata, +7

Oncotarget

Drug LibrarySynthetic LethalityRedox BiologyOxidative StressMedicinal Chemistry +16

Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti–PD-1 Immunotherapy in Fibrotic Tumors

Takahiko Akiyama, Tadahito Yasuda, Tomoyuki Uchihara, +23

Cancer Research

Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer

Fumimasa Kitamura, Takashi Semba, Noriko Yasuda‐Yoshihara, +23

JCI Insight

TGFβ Signaling Activated by Cancer-Associated Fibroblasts Determines the Histological Signature of Lung Adenocarcinoma

Ryo Sato, Kosuke Imamura, Takashi Semba, +8

Cancer Research

EGFR is a master switch between immunosuppressive and immunoactive tumor microenvironment in inflammatory breast cancer

Xiaoping Wang, Takashi Semba, Ganiraju C. Manyam, +21

Science Advances

Ibc TmeBreast OncologyMedicineImmunologyInflammatory Breast Cancer +12

Pulmonary hepatoid adenocarcinoma: report of a case

Yamato Motooka, Kentaro Yoshimoto, Takashi Semba, +5

Surgical Case Reports

Surgical OncologyAdjuvant ChemotherapyPathologyTumor BiologyOncology +17

IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment

Jun Zhang, Lingfeng Fu, Noriko Yasuda‐Yoshihara, +17

Gastric Cancer

Macrophage BiologyInflammationCytokineImmunologyTumor Immunity +10

Identification of the JNK-Active Triple-Negative Breast Cancer Cluster Associated With an Immunosuppressive Tumor Microenvironment

Takashi Semba, Xiaoping Wang, Xuemei Xie, +7

JNCI Journal of the National Cancer Institute