Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors

Yi‐You Huang, Yan-Fa Yu, Chen Zhang, +9

Journal of Medicinal Chemistry

Salvianolic acid B protects cardiomyocytes from angiotensin II-induced hypertrophy via inhibition of PARP-1

Min Liu, Jiantao Ye, Si Gao, +12

Biochemical and Biophysical Research Communications

CardiomyopathyMolecular PhysiologyMedicinePhysiologyCardiovascular Pharmacology +8

mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway

Hanwei Yang, Huiling Hong, Wenwei Luo, +7

Acta Pharmacologica Sinica

Endothelial Cell PathobiologySignal TransductionAkt/gsk-3β/c/ebpα Signaling PathwaySignaling PathwayEndothelial Cell Senescence +11

Downregulation of adipose triglyceride lipase promotes cardiomyocyte hypertrophy by triggering the accumulation of ceramides

Hui Gao, Xiaojun Feng, Zhuo-ming Li, +9

Archives of Biochemistry and Biophysics

Metabolic SyndromeCardiomyocyte HypertrophyBiochemistryLipid MetabolismPhysiology +7

AG-690/11026014, a novel PARP-1 inhibitor, protects cardiomyocytes from AngII-induced hypertrophy

Min Liu, Zhe Li, Guo-Wen Chen, +5

Molecular and Cellular Endocrinology

CardiomyopathyMolecular PhysiologyCardiovascular DiseaseMedicinePhysiology +6

C33(S), a novel PDE9A inhibitor, protects against rat cardiac hypertrophy through upregulating cGMP signaling

Panxia Wang, Zhuo-ming Li, Sidong Cai, +7

Acta Pharmacologica Sinica

Molecular PharmacologyCardiomyopathyCardiac MuscleMolecular PhysiologySignal Transduction +8

Upregulation of heme oxygenase-1 potentiates EDH-type relaxations in the mesenteric artery of the spontaneously hypertensive rat

Zhuo-ming Li, Yu Wang, Ricky Y.K. Man, +1

American Journal of Physiology-Heart and Circulatory Physiology

HypertensionVascular RelaxationsHypertensive RatRedox BiologyOxidative Stress +14

PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy

Qian Li, Zhuo-ming Li, Shuya Sun, +7

Acta Pharmacologica Sinica

Cardiac MuscleNuclear ExportCardiomyopathyPathological Myocardial HypertrophyNatural Sciences +7

Peroxisome proliferator–activated receptor gamma coactivator 1 alpha protects cardiomyocytes from hypertrophy by suppressing calcineurin-nuclear factor of activated T cells c4 signaling pathway

Xueping Liu, Hui Gao, Xiaoyang Huang, +5

Translational research

Cardiac MuscleActivated T CellsCardiomyopathySignal TransductionMolecular Physiology +10

Synthesis of the novel PARP-1 inhibitor AG-690/11026014 and its protective effects on angiotensin II-induced mouse cardiac remodeling

Guoshuai Feng, Cuige Zhu, Zhuo-ming Li, +7

Acta Pharmacologica Sinica

Molecular PharmacologyMolecular PhysiologyMedicineImmunologyCardiovascular Pharmacology +7