Helminth 2‐Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages

Sheila Donnelly, Colin M. Stack, Sandra M. O’Neill, +3

The FASEB Journal

Schistosoma MansoniInnate Immune SystemImmunologyImmune RegulationImmunologic Mechanism +18

Cathepsin L1, the Major Protease Involved in Liver Fluke (Fasciola hepatica) Virulence

Peter R. Collins, Colin M. Stack, Sandra M. O’Neill, +8

Journal of Biological Chemistry

Structural basis for the inhibition of the essential <i>Plasmodium falciparum</i> M1 neutral aminopeptidase

Sheena McGowan, Corrine J. Porter, Jonathan Lowther, +14

Proceedings of the National Academy of Sciences

Protein FunctionAmino AcidsBiochemistryProtein AssemblyProtease Active Site +12

Helminth Cysteine Proteases Inhibit TRIF-dependent Activation of Macrophages via Degradation of TLR3

Sheila Donnelly, Sandra M. O’Neill, Colin M. Stack, +4

Journal of Biological Chemistry

InflammationSchistosoma MansoniCytokineAutoimmune DiseaseInnate Immune System +13

Proteomics and Phylogenetic Analysis of the Cathepsin L Protease Family of the Helminth Pathogen Fasciola hepatica

Mark W. Robinson, José F. Tort, Jonathan Lowther, +7

Molecular & Cellular Proteomics

Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1)

Olwen Golden, Robin J. Flynn, Carolyn Read, +5

Vaccine

VaccinationVeterinary VaccineAnimal SciencePathogenesisImmunology +12

Characterization of the Plasmodium falciparum M17 Leucyl Aminopeptidase

Colin M. Stack, Jonathan Lowther, Eithne Cunningham, +11

Journal of Biological Chemistry

Protein ChemistryAmino AcidsBiochemistryAntiparasitic AgentNatural Sciences +12

Identification of Phosphinate Dipeptide Analog Inhibitors Directed against the <i>Plasmodium </i><i>falciparum</i> M17 Leucine Aminopeptidase as Lead Antimalarial Compounds

Tina S. Skinner‐Adams, Jonathan Lowther, Franka Teuscher, +7

Journal of Medicinal Chemistry

Structure of the <i>Plasmodium falciparum</i> M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

Sheena McGowan, Christine A. Oellig, Woldeamanuel A. Birru, +12

Proceedings of the National Academy of Sciences

Protein AssemblyBiomolecular Structure PredictionAntiparasitic AgentMalariaActive Sites +14

Structural and Functional Relationships in the Virulence-associated Cathepsin L Proteases of the Parasitic Liver Fluke, Fasciola hepatica

Colin M. Stack, Conor R. Caffrey, Sheila Donnelly, +12

Journal of Biological Chemistry