Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer

Yibing Hu, Yan Chang, Lei Mu, +5

PLoS ONE

PathologyExtracellular MicrovesiclesCancer BiologyTumor BiologyFibroblast-derived Exosomes Contribute +15

The PSA−/lo Prostate Cancer Cell Population Harbors Self-Renewing Long-Term Tumor-Propagating Cells that Resist Castration

Jichao Qin, Xin Liu, Brian Laffin, +13

Cell stem cell

UrologyOncologyGenitourinary CancerMedicineResist Castration +5

Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance

Yun-Huang Hu, Chao Yan, Lan Mu, +8

Oncogene

Regulator of G-protein signaling 2 (RGS2) inhibits androgen-independent activation of androgen receptor in prostate cancer cells

Xuni Cao, Jichao Qin, Yan Xie, +5

Oncogene

Androgen ReceptorSignal TransductionG Protein-coupled ReceptorHormonal ReceptorAndrogen-independent Activation +8

Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development

Qin Yan, Lili Gong, Mi Deng, +13

Proceedings of the National Academy of Sciences

Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells

Xin Liu, Xin Chen, Kiera Rycaj, +16

Oncotarget

Pca Cell HeterogeneityTumorigenic HeterogeneityUrologyOncologyLineage Plasticity +11

Lactate promotes metastasis of normoxic colorectal cancer stem cells through PGC-1α-mediated oxidative phosphorylation

Shuang Liu, Hui Zhao, Yibing Hu, +5

Cell Death and Disease

Differentiated cancer cell-originated lactate promotes the self-renewal of cancer stem cells in patient-derived colorectal cancer organoids

Hui Zhao, Yan Chang, Yibing Hu, +7

Cancer Letters

Lineage PlasticityMedicineCancer Cell-originated LactateColorectal CancerStem Cell Research +8

Drug-Tolerant Cancer Cells Show Reduced Tumor-Initiating Capacity: Depletion of CD44+ Cells and Evidence for Epigenetic Mechanisms

Hong Yan, Xin Chen, Qiuping Zhang, +11

PLoS ONE

Protein Phosphatase-2A Is a Target of Epigallocatechin-3-Gallate and Modulates p53-Bak Apoptotic Pathway

Jichao Qin, He-Ge Chen, Qin Yan, +6

Cancer Research

MitophagyProtein Phosphatase-2aP53-dependent ApoptosisChemoprevention StrategyApoptosis +18