Zachary J. Frangos

AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach, Denzil Bernard, Kong T. Nguyen et al. · Scientific Reports · 2024 · 120 citations · Full text

Pharmacy, Bioinformatics, Medicinal Chemistry +16

Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics

Shannon N. Mostyn, Katie A. Wilson, Alexandra Schumann-Gillett et al. · eLife · 2019 · 39 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Development of an <i>N</i>-Acyl Amino Acid That Selectively Inhibits the Glycine Transporter 2 To Produce Analgesia in a Rat Model of Chronic Pain

Shannon N. Mostyn, Tristan Rawling, Sarasa A. Mohammadi et al. · Journal of Medicinal Chemistry · 2019 · 37 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

The allosteric inhibition of glycine transporter 2 by bioactive lipid analgesics is controlled by penetration into a deep lipid cavity

Katie A. Wilson, Shannon N. Mostyn, Zachary J. Frangos et al. · Journal of Biological Chemistry · 2021 · 12 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

The efficacy of the analgesic <scp>GlyT2</scp> inhibitor, <scp>ORG25543</scp> , is determined by two connected allosteric sites

Ryan Cantwell Chater, Ada Quinn, Katie A. Wilson et al. · Journal of Neurochemistry · 2023 · 11 citations · Full text

Medicine, Biochemistry, Pharmacology +17