Heleen A. Bardelmeijer

Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir.

Heleen A. Bardelmeijer, Mariët Ouwehand, Tessa Buckle et al. · PubMed · 2002 · 135 citations

P-glycoprotein Knockout Mice, Oral Docetaxel, Pharmacotherapy +17

Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein.

Heleen A. Bardelmeijer, Jos H. Beijnen, Kenneth R. Brouwer et al. · PubMed · 2000 · 121 citations

Molecular Pharmacology, Tumor Biology, Oral Bioavailability +15

Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice

Heleen A. Bardelmeijer, Mariët Ouwehand, Jos H. Beijnen et al. · Investigational New Drugs · 2004 · 80 citations

Pharmacological Study, Medicine, Pharmacology +7

The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients

Mirte M. Malingré, J. Schellens, Olaf van Tellingen et al. · British Journal of Cancer · 2001 · 71 citations · Full text

Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut

Heleen A. Bardelmeijer, Mariët Ouwehand, Mirte M. Malingré et al. · Cancer Chemotherapy and Pharmacology · 2001 · 63 citations

Gastrointestinal Pharmacology, Medicine, Physiology +4