Douwe J. Dijkstra

Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains

Leoni Abendstein, Douwe J. Dijkstra, Rayman T.N. Tjokrodirijo et al. · Nature Communications · 2023 · 55 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation

Dylan P. Noone, Douwe J. Dijkstra, Teun T. van der Klugt et al. · Proceedings of the National Academy of Sciences · 2022 · 45 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Expression and production of the SERPING1-encoded endogenous complement regulator C1-inhibitor in multiple cohorts of tuberculosis patients

Rosalie Lubbers, Jayne S. Sutherland, Delia Goletti et al. · Molecular Immunology · 2020 · 33 citations · Full text

Life Sciences, Immunology, Infectious Diseases +14

Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein

Dylan P. Noone, Marjolein M. E. Isendoorn, Sebastiaan M. W. R. Hamers et al. · Proceedings of the National Academy of Sciences · 2024 · 21 citations · Full text

Life Sciences, Biochemistry, Immunology +17

Carbamylation reduces the capacity of IgG for hexamerization and complement activation

Rosalie Lubbers, Simone C. Oostindie, Douwe J. Dijkstra et al. · Clinical & Experimental Immunology · 2019 · 20 citations · Full text

Life Sciences, Immunology, Pathobiology +16