Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice

Yuyong Tao, Monika Mis, Levi L. Blazer, +12

eLife

ImmunologyWnt/frizzled PathwaysImmunologic MechanismBiological TherapyImmunotherapy +21

Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b

Shikai Hu, Silvia Liu, Yu Bian, +10

Cell Reports Medicine

Endothelial CellsSpatial OmicsTranscriptional RegulationSignaling PathwayCell Regulation +20

Reversible, Allosteric Small-Molecule Inhibitors of Regulator of G Protein Signaling Proteins

Levi L. Blazer, David L. Roman, Alfred Chung, +4

Molecular Pharmacology

Targeted alveolar regeneration with Frizzled-specific agonists

Ahmad N. Nabhan, Joshua D. Webster, Jarrett Adams, +14

Cell

A Nanomolar-Potency Small Molecule Inhibitor of Regulator of G-Protein Signaling Proteins

Levi L. Blazer, Haoming Zhang, Emma M. Casey, +2

Biochemistry

Cysteine ReactivityMolecular RegulationMolecular BiologyPeptide ScienceMolecular Pharmacology +18

A Descriptor Set for Quantitative Structure‐property Relationship Prediction in Biologics

Kannan Sankar, Kyle Trainor, Levi L. Blazer, +5

Molecular Informatics

Descriptor SetDrug TargetMolecular BiologyBioinformatics DatabaseBiostatistics +17

A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties

Zvezdan Pavlovic, Jarrett Adams, Levi L. Blazer, +9

mAbs

EngineeringImmunologyAnti-tumor PropertiesImmunotherapeuticsBiomedical Engineering +20

A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy

Rony Chidiac, Md. Joynal Abedin, Graham MacLeod, +11

EMBO Molecular Medicine

InflammationOcular DiseaseRetinaNorrin/wnt Surrogate AntibodyOphthalmology +5

Small Molecule Inhibitors of Regulators of G Protein Signaling (RGS) Proteins

Emma M. Turner, Levi L. Blazer, Richard R. Neubig, +1

ACS Medicinal Chemistry Letters

Selectivity and Anti-Parkinson’s Potential of Thiadiazolidinone RGS4 Inhibitors

Levi L. Blazer, Andrew J. Storaska, Emily M. Jutkiewicz, +9

ACS Chemical Neuroscience