CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease

Soosung Kang, Garry Cooper, Sara F. Dunne, +4

Nature Communications

Molecular PharmacologyMolecular NeuroscienceHyperpolarization (Biology)Functional SelectivityMedicine +6

Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels CaV1.3 and CaV1.2

Che-Chien Chang, Song Cao, Soosung Kang, +7

Bioorganic & Medicinal Chemistry

BiochemistryNatural SciencesIon ChannelsOrganic Chemistry4-Substituted 1,4-Dihydropyridine-3,5-dicarboxylates +1

Antagonism of L-type Ca2+ channels CaV1.3 and CaV1.2 by 1,4-dihydropyrimidines and 4H-pyrans as dihydropyridine mimics

Soosung Kang, Garry Cooper, Sara F. Dunne, +3

Bioorganic & Medicinal Chemistry

Molecular PharmacologyBiochemistryMedicineNatural SciencesIon Channels +3

Genes Involved in Maintaining Mitochondrial Membrane Potential Upon Electron Transport Chain Disruption

Karthik Vasan, Matt Clutter, Sara F. Dunne, +4

Frontiers in Cell and Developmental Biology

MitophagyMitochondrial DysfunctionGeneticsMolecular BiologyCell Death +17

Structure–Activity Relationship of N,N′-Disubstituted Pyrimidinetriones as Ca_V1.3 Calcium Channel-Selective Antagonists for Parkinson’s Disease

Soosung Kang, Garry Cooper, Sara F. Dunne, +3

Journal of Medicinal Chemistry

Novel High Content Screen Detects Compounds That Promote Neurite Regeneration from Cochlear Spiral Ganglion Neurons

Donna S. Whitlon, Mary Grover, Sara F. Dunne, +3

Scientific Reports

Ligand Screening Using Fluorescence Thermal Shift Analysis (FTS)

Chi-Hao Luan, S.H. Light, Sara F. Dunne, +1

Methods in molecular biology

EngineeringBiochemistrySingle-molecule DetectionAnalytical ChemistryBioimaging +4

Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer

Ratika Kunder, Michelle Velyunskiy, Sara F. Dunne, +17

Cell chemical biology

Proteasome InhibitionBreast OncologyMedicineTherapeutic StrategySynergistic Pim Kinase +10

Ilaprazole and Other Novel Prazole-Based Compounds That Bind Tsg101 Inhibit Viral Budding of Herpes Simplex Virus 1 and 2 and Human Immunodeficiency Virus from Cells

Jonathan Leis, Chi‐Hao Luan, James E. Audia, +2

Journal of Virology

Identifying Anti-prion Chemical Compounds Using a Newly Established Yeast High-Throughput Screening System

Zhiqiang Du, Stephanie Valtierra, Luzivette Robles Cardona, +3

Cell chemical biology

BiochemistryBioassay-guided IsolationMedicineNatural SciencesBioanalysis +8