Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis

Elena V. Polishchuk, Assunta Merolla, Josef Lichtmannegger, +21

Gastroenterology

From Atp7b-deficient AnimalsMitophagyApoptosisPathologyCell Death +14

Liver mitochondrial membrane crosslinking and destruction in a rat model of Wilson disease

Hans Zischka, Josef Lichtmannegger, Sabine Schmitt, +15

Journal of Clinical Investigation

PathologyMolecular BiologyMitochondrial BiologyRedox BiologyRat Model +22

Methanobactin reverses acute liver failure in a rat model of Wilson disease

Josef Lichtmannegger, Christin Leitzinger, Ralf Wimmer, +28

Journal of Clinical Investigation

PathologyRedox BiologyRat ModelCopper HomeostasisOxidative Stress +19

Progressive stages of mitochondrial destruction caused by cell toxic bile salts

Sabine Schulz, Sabine Schmitt, Ralf Wimmer, +11

Biochimica et Biophysica Acta (BBA) - Biomembranes

Mitochondrial DestructionMitochondrial FunctionBiochemistryBiliary TractLiver Physiology +10

Tracing Copper−Thiomolybdate Complexes in a Prospective Treatment for Wilson’s Disease

Limei Zhang, Josef Lichtmannegger, Karl H. Summer, +3

Biochemistry

Iron MetabolismChemical BiologyX-ray FluorescenceOxidative StressBioanalysis +14

The exceptional sensitivity of brain mitochondria to copper

Sabine Borchard, Francesca Bork, Tamara Rieder, +8

Toxicology in Vitro

A High-Calorie Diet Aggravates Mitochondrial Dysfunction and Triggers Severe Liver Damage in Wilson Disease Rats

Claudia Einer, Christin Leitzinger, Josef Lichtmannegger, +20

Cellular and Molecular Gastroenterology and Hepatology

Metabolic SyndromeNutritionWilson Disease RatsHepatologyBiochemistry +9

Tetrathiomolybdate Causes Formation of Hepatic Copper−Molybdenum Clusters in an Animal Model of Wilson's Disease

Graham N. George, Ingrid J. Pickering, Hugh H. Harris, +4

Journal of the American Chemical Society

Dissolution of copper-rich granules in hepatic lysosomes by D-penicillamine prevents the development of fulminant hepatitis in Long-Evans cinnamon rats

Dominik Klein, Josef Lichtmannegger, U. Heinzmann, +1

Journal of Hepatology

HepatologyBiochemistryLong-evans Cinnamon RatsMedicineLiver Physiology +7

A semi-automated method for isolating functionally intact mitochondria from cultured cells and tissue biopsies

Sabine Schmitt, Friederike Saathoff, Lilja Meissner, +11

Analytical Biochemistry

Intact MitochondriaMitochondrial TransplantationCell DivisionMitochondrial FunctionTissue Biopsies +7