Tayfun Özçelık

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Qian Zhang, Paul Bastard, Zhiyong Liu et al. · Science · 2020 · 2.4K citations · Full text

Human Loci, Disease Susceptibility, Inborn Errors +14

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Paul Bastard, Adrian Gervais, Tom Le Voyer et al. · Science Immunology · 2021 · 600 citations · Full text

Trembler mouse carries a point mutation in a myelin gene

Ueli Suter, Andrew A. Welcher, Tayfun Özçelık et al. · Nature · 1992 · 422 citations

Knockout Mouse, Genetic Disorder, Neuroanatomy +9

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

Takaki Asano, Bertrand Boisson, Fanny Onodi et al. · Science Immunology · 2021 · 410 citations · Full text

Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder

Alina Patke, Patricia Murphy, Onur Emre Onat et al. · Cell · 2017 · 365 citations · Full text

Sleep Disorders, Sleep Medicine, Sleep +10