Conggang Zhang

Structural basis of STING binding with and phosphorylation by TBK1

Conggang Zhang, Guijun Shang, Xiang Gui et al. · Nature · 2019 · 1.1K citations

Life Sciences, Biochemistry, Molecular Biology +12

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

Guijun Shang, Conggang Zhang, Zhijian J. Chen et al. · Nature · 2019 · 740 citations

Life Sciences, Biochemistry, Molecular Biology +7

NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking

Lulu Zhang, Xubiao Wei, Zhimeng Wang et al. · Cell Reports · 2023 · 171 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated antitumour immunity

Chaoyu Wang, Ruoshi Zhang, Jia He et al. · Nature Communications · 2023 · 161 citations · Full text

Medicine, Oncology, Pharmacology +16

SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing

Yanfei Hou, Zhimeng Wang, Peiyuan Liu et al. · Immunity · 2023 · 110 citations

Life Sciences, Biochemistry, Molecular Biology +14