John M. Pascal

Structural Basis for DNA Damage–Dependent Poly(ADP-ribosyl)ation by Human PARP-1

Marie-France Langelier, Jamie L. Planck, Swati Roy et al. · Science · 2012 · 681 citations

Life Sciences, Biochemistry, Molecular Biology +17

Dual Roles of PARP-1 Promote Cancer Growth and Progression

Matthew J. Schiewer, Jonathan F. Goodwin, Sumin Han et al. · Cancer Discovery · 2012 · 446 citations · Full text

Medicine, Cancer Biology, Oncology +17

Human DNA ligase I completely encircles and partially unwinds nicked DNA

John M. Pascal, Patrick O’Brien, Alan E. Tomkinson et al. · Nature · 2004 · 357 citations

Life Sciences, Genetics, Molecular Biology +8

PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain

Jennine M. Dawicki-McKenna, Marie-France Langelier, Jamie E. DeNizio et al. · Molecular Cell · 2015 · 353 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +8

Structural basis for allosteric PARP-1 retention on DNA breaks

Levani Zandarashvili, Marie-France Langelier, Uday Kiran Velagapudi et al. · Science · 2020 · 331 citations · Full text

Life Sciences, Molecular Biology, Oncology +17