John M. Pascal

Structural Basis for DNA Damage–Dependent Poly(ADP-ribosyl)ation by Human PARP-1

Marie-France Langelier, Jamie L. Planck, Swati Roy et al. · Science · 2012 · 659 citations

Crystal Structure, Biochemistry, Protein Assembly +11

Dual Roles of PARP-1 Promote Cancer Growth and Progression

Matthew J. Schiewer, Jonathan F. Goodwin, Sumin Han et al. · Cancer Discovery · 2012 · 439 citations · Full text

Human DNA ligase I completely encircles and partially unwinds nicked DNA

John M. Pascal, Patrick O’Brien, Alan E. Tomkinson et al. · Nature · 2004 · 350 citations

Chromatin, Genome Instability, Dna Sequencing +9

PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain

Jennine M. Dawicki-McKenna, Marie-France Langelier, Jamie E. DeNizio et al. · Molecular Cell · 2015 · 339 citations · Full text

Protein Function, Signal Transduction, Signal Recognition +4

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1

Sebastian Eustermann, Wing-Fung Wu, Marie-France Langelier et al. · Molecular Cell · 2015 · 320 citations · Full text