Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex–mediated immune responses

Laurence Blumberg, James E. Humphries, Susan Dana Jones, +20

Science Advances

The Specificity of Trimming of MHC Class I-Presented Peptides in the Endoplasmic Reticulum

Arron Hearn, Ian A. York, Kenneth L. Rock

The Journal of Immunology

Presented PeptidesImmunologyMolecular BiologyAntigen ProcessingEpitope Precursors +14

Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury

Anissa A. Widjaja, Jinrui Dong, Eleonora Adami, +20

Science Translational Medicine

Placental Leucine Aminopeptidase Efficiently Generates Mature Antigenic Peptides In Vitro but in Patterns Distinct from Endoplasmic Reticulum Aminopeptidase 1

Dimitra G. Georgiadou, Arron Hearn, Irini Evnouchidou, +5

The Journal of Immunology

Epitope DependentImmunologyMolecular BiologyPatterns DistinctAntigen Processing +16

Analysis of the Role of Tripeptidyl Peptidase II in MHC Class I Antigen Presentation In Vivo

Masahiro Kawahara, Ian A. York, Arron Hearn, +2

The Journal of Immunology

Isolation of blood-brain barrier-crossing antibodies from a phage display library by competitive elution and their ability to penetrate the central nervous system

George Thom, Jon P. Hatcher, Arron Hearn, +5

mAbs

Immunocytochemical TechniqueEngineeringImmunologyCompetitive ElutionBrain Exposure +19

Mutant<i>Escherichia coli</i>Heat-Labile Toxin B Subunit That Separates Toxoid-Mediated Signaling and Immunomodulatory Action from Trafficking and Delivery Functions

Sylvia Fraser, Lolke de Haan, Arron Hearn, +5

Infection and Immunity

B SubunitsProtein SecretionMicrobial PathogensDelivery FunctionsImmunology +23

Enhanced Delivery of Exogenous Peptides into the Class I Antigen Processing and Presentation Pathway

Lolke de Haan, Arron Hearn, A. Jennifer Rivett, +1

Infection and Immunity

Exogenous EpitopesPeptide EngineeringImmunologyImmunodominanceImmunologic Mechanism +25

Selective blood-brain barrier permeabilization of brain metastases by a type 1 receptor-selective tumor necrosis factor mutein

Mario Muñoz, Sandra J. Campbell, Christina Simoglou Karali, +13

Neuro-Oncology

Characterizing the Specificity and Cooperation of Aminopeptidases in the Cytosol and Endoplasmic Reticulum during MHC Class I Antigen Presentation

Arron Hearn, Ian A. York, Courtney Bishop, +1

The Journal of Immunology