Darlene Barnard

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

Alastair J. King, Huaiyu Sun, Bruce Diaz et al. · Nature · 1998 · 430 citations

Signal Transduction, Signaling Pathway, Cell Regulation +8

Phosphorylation of Raf-1 Serine 338-Serine 339 Is an Essential Regulatory Event for Ras-Dependent Activation and Biological Signaling

Bruce Diaz, Darlene Barnard, Adele J. Filson et al. · Molecular and Cellular Biology · 1997 · 197 citations · Full text

Molecular Regulation, Essential Regulatory Event, Molecular Biology +18

LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms

Constance King, H. Bruce Diaz, Samuel McNeely et al. · Molecular Cancer Therapeutics · 2015 · 183 citations · Full text

Dna Damage, Molecular Biology, Cell Death +18

Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues.

Ellen Chuang, Darlene Barnard, L Hettich et al. · Molecular and Cellular Biology · 1994 · 179 citations · Full text

Molecular Regulation, Genetics, Critical Binding +18

Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor

Constance King, Henry Diaz, Darlene Barnard et al. · Investigational New Drugs · 2013 · 109 citations

Molecular Pharmacology, Drug Target, Preclinical Development +8