Gabriele Twigg

Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease

Adel Ersek, Ke Xu, Aristotelis Antonopoulos et al. · Journal of Clinical Investigation · 2015 · 52 citations · Full text

Bone Disease, Signal Transduction Events, Lipid Rafts +15

Amphiphilic 1-Deoxynojirimycin Derivatives through Click Strategies for Chemical Chaperoning in N370S Gaucher Cells

Jennifer D. Diot, M. Isabel García‐Moreno, Gabriele Twigg et al. · The Journal of Organic Chemistry · 2011 · 50 citations · Full text

Bioorganic Chemistry, Glycobiology, Amphiphilic 1-Deoxynojirimycin Derivatives +21

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors

Jérôme Désiré, Martine Mondon, Nathalie Fontelle et al. · Organic & Biomolecular Chemistry · 2014 · 28 citations

Bioorganic Chemistry, Glycobiology, Organic Chemistry +22

Synthesis of N-substituted ε-hexonolactams as pharmacological chaperones for the treatment of N370S mutant Gaucher disease

Guan‐Nan Wang, Gabriele Twigg, Terry D. Butters et al. · Organic & Biomolecular Chemistry · 2012 · 23 citations

Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher’s disease

T. Rasmussen, Sarah Allman, Gabriele Twigg et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 22 citations · Full text

N-alkylated Noeurostegines, Medicinal Chemistry, Gaucher ’ +2