Lack of beta-arrestin signaling in the absence of active G proteins

Manuel Grundmann, Nicole Merten, Davide Malfacini, +21

Nature Communications

Decoding Signaling and Function of the Orphan G Protein–Coupled Receptor GPR17 with a Small-Molecule Agonist

Stephanie Hennen, Haibo Wang, Lucas Peters, +20

Science Signaling

Molecular BiologySmall-molecule AgonistSynaptic SignalingCellular PhysiologySocial Sciences +20

The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides

Max Meyrath, Martyna Szpakowska, Julian Zeiner, +11

Nature Communications

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

Andreas Böck, Nicole Merten, Ramona Schrage, +16

Nature Communications

The Gq signalling pathway inhibits brown and beige adipose tissue

Katarina Klepac, Ana Kilić, Thorsten Gnad, +16

Nature Communications

Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases

Elisabeth Christiansen, Kenneth R. Watterson, Claire J. Stocker, +12

British Journal Of Nutrition

NutritionMetabolic DiseasesGlucose ToleranceInsulin SignalingGastrointestinal Peptide Hormone +17

Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs

Eva Marie Pfeil, Julian Brands, Nicole Merten, +26

Molecular Cell

Signal TransductionMolecular PhysiologyBiochemistryG Protein-coupled ReceptorCell Signaling +9

The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules

Katharina Simon, Stephanie Hennen, Nicole Merten, +4

Journal of Biological Chemistry

FZD ₅ is a Gα _q -coupled receptor that exhibits the functional hallmarks of prototypical GPCRs

Shane C. Wright, Maria Consuelo Alonso Cañizal, Tobias Benkel, +12

Science Signaling

How Carvedilol activates β2-adrenoceptors

Tobias Benkel, Mirjam Zimmermann, Julian Zeiner, +27

Nature Communications