Single-Cell Transcriptomics of the Human Endocrine Pancreas

Yue J. Wang, Jonathan Schug, Kyoung‐Jae Won, +5

Diabetes

Transcriptional RegulationSystems BiologyFunctional GenomicsDevelopmental BiologyPancreatic Cancer +13

Mutation of the Prion Protein in Libyan Jews with Creutzfeldt–Jakob Disease

Karen Hsiao, Zeev Meiner, Esther Kahana, +7

New England Journal of Medicine

Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function

Dana Avrahami, Changhong Li, Jia Zhang, +8

Cell Metabolism

AgingChromatin StateEpigenetic ChangeAging-dependent DemethylationEpigenetics +14

PAX6 maintains β cell identity by repressing genes of alternative islet cell types

Avital Swisa, Dana Avrahami, Noa Eden, +9

Journal of Clinical Investigation

Tf Pax6Cell SpecializationCellular PhysiologyInsulin SignalingMetabolic Syndrome +22

Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D

Dana Avrahami, Yue J. Wang, Jonathan Schug, +6

Molecular Metabolism

Fatal Prion Disease in a Mouse Model of Genetic E200K Creutzfeldt-Jakob Disease

Yael Friedman‐Levi, Zeev Meiner, Tamar Canello, +5

PLoS Pathogens

Creutzfeldt-jakob DiseaseGeneticsPathologyMolecular GeneticsDisease Gene Identification +17

Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state

Xiao-Qing Dai, Joan Camuñas-Soler, Linford J.B. Briant, +21

Cell Metabolism

The Role of Syntaxins in the Specificity of Vesicle Targeting in Polarized Epithelial Cells

Martin B.A. ter Beest, Steven J. Chapin, Dana Avrahami, +1

Molecular Biology of the Cell

Protein SecretionVesicle TargetingMolecular BiologyCytoskeletonSyntaxin 3 +14

Targeted demethylation at the CDKN1C/p57 locus induces human β cell replication

Kristy Ou, Ming Yu, Nicholas Moss, +11

Journal of Clinical Investigation

Targeting the cell cycle inhibitor p57Kip2 promotes adult human β cell replication

Dana Avrahami, Changhong Li, Ming Yu, +6

Journal of Clinical Investigation

Immune RegulationImmunologyMolecular BiologyCell DeathCell Cycle +18