SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

Hanna-Mari Baldauf, Xiaoyu Pan, Elina Erikson, +17

Nature Medicine

Human RetrovirusImmunologyAntiviral ResponseHiv-1 InfectionChronic Viral Infection +4

The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation

Tommy E. White, Alberto Brandariz-Núñez, José Carlos Valle‐Casuso, +5

Cell Host & Microbe

Viral ReplicationMolecular VirologyRetroviral Restriction AbilityGeneticsNatural Sciences +7

Macrophage Tropism of HIV-1 Depends on Efficient Cellular dNTP Utilization by Reverse Transcriptase

Tracy L. Diamond, Mikhail Roshal, Varuni K. Jamburuthugoda, +8

Journal of Biological Chemistry

Viral ReplicationHuman RetrovirusHiv-1 DependsImmunologyReverse Transcriptase +9

The Ambiguous Base-Pairing and High Substrate Efficiency of T-705 (Favipiravir) Ribofuranosyl 5′-Triphosphate towards Influenza A Virus Polymerase

Zhinan Jin, Lucas K. Smith, Vivek K. Rajwanshi, +2

PLoS ONE

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

Jeongmin Ryoo, Jongsu Choi, Changhoon Oh, +13

Nature Medicine

Viral ReplicationHiv-1 RestrictionHuman RetrovirusPathogenesisImmunology +6

PB2 Residue 271 Plays a Key Role in Enhanced Polymerase Activity of Influenza A Viruses in Mammalian Host Cells

Kendra A. Bussey, Tatiana Bousse, Emily A. Desmet, +2

Journal of Virology

Crystal Structure of LexA

Yu Luo, Richard A. Pfuetzner, S. Mosimann, +6

Cell

Crystal StructureStructure ElucidationChemistryCrystallographyCrystal Structure Design

SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination

Waaqo Daddacha, Allyson E. Koyen, Amanda J. Bastien, +25

Cell Reports

Tight Interplay among SAMHD1 Protein Level, Cellular dNTP Levels, and HIV-1 Proviral DNA Synthesis Kinetics in Human Primary Monocyte-derived Macrophages

Baek Kim, Laura A. Nguyen, Waaqo Daddacha, +1

Journal of Biological Chemistry

InflammationViral ReplicationHuman RetrovirusTight InterplayImmunology +9

Activation of the ATR-mediated DNA Damage Response by the HIV-1 Viral Protein R

Mikhail Roshal, Baek Kim, Yonghong Zhu, +2

Journal of Biological Chemistry

G2 PhaseViral ReplicationDna DamageCell RegulationMedicine +12