Frances A. Bromidge

Loss of the Major GABA_AReceptor Subtype in the Brain Is Not Lethal in Mice

Cyrille Sur, Keith A. Wafford, David S. Reynolds et al. · Journal of Neuroscience · 2001 · 232 citations · Full text

Synaptic Transmission, Alpha Subunits, Neurotransmission +16

Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression

Martin R. Guscott, Linda J. Bristow, Karen L. Hadingham et al. · Neuropharmacology · 2005 · 227 citations

Psychiatry, Functional Selectivity, Medicine +12

3-Heteroaryl-2-pyridones:  Benzodiazepine Site Ligands with Functional Selectivity for α2/α3-Subtypes of Human GABA_A Receptor-Ion Channels

Ian Collins, Christopher R. Moyes, William B. Davey et al. · Journal of Medicinal Chemistry · 2002 · 109 citations · Full text

Pharmacotherapy, Social Sciences, Molecular Pharmacology +16

Synthesis and Biological Evaluation of 3-Heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-<i>a</i>]phthalazines and Analogues as Subtype-Selective Inverse Agonists for the GABA_Aα5 Benzodiazepine Binding Site

Leslie J. Street, Francine Sternfeld, Richard A. Jelley et al. · Journal of Medicinal Chemistry · 2004 · 70 citations · Full text

Combinatorial Chemistry, Organic Chemistry, Pharmacotherapy +19

Discovery of Functionally Selective 7,8,9,10-Tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-<i>a</i>]phthalazines as GABA_AReceptor Agonists at the α₃Subunit

Michael G. N. Russell, Robert W. Carling, John Atack et al. · Journal of Medicinal Chemistry · 2005 · 61 citations · Full text

Combinatorial Chemistry, Molecular Pharmacology, Medicinal Chemistry +14