Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

Yi Zhou, Mingjian Fei, Gu Zhang, +25

Immunity

InflammationPhagocytic Receptor MertkCytokineMedicineImmunology +8

Immune heterogeneity in small-cell lung cancer and vulnerability to immune checkpoint blockade

Barzin Y. Nabet, Habib Hamidi, Myung Chang Lee, +24

Cancer Cell

Cancer ImmunosurveillanceMedicineImmune HeterogeneityImmunologyBronchial Neoplasm +7

Anti-VEGF Treatment Enhances CD8+ T-cell Antitumor Activity by Amplifying Hypoxia

Patricia E. de Almeida, Judy Mak, Genevive Hernandez, +6

Cancer Immunology Research

Mechanical Forces Regulate Elastase Activity and Binding Site Availability in Lung Elastin

Rajiv Jesudason, Susumu Satô, Harikrishnan Parameswaran, +5

Biophysical Journal

MechanobiologyBinding Site AvailabilityEngineeringLung ElastinPhysiology +10

Micropatterned cell sheets with defined cell and extracellular matrix orientation exhibit anisotropic mechanical properties

Brett C. Isenberg, Daniel E. Backman, Michelle E. Kinahan, +5

Journal of Biomechanics

Tissue EngineeringMechanobiologyEngineeringMicromechanicsMechanical Properties +11

Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView

Takamasa Kudo, Ana M. Meireles, Reuben Moncada, +35

Nature Biotechnology

Tissue ImagingEngineeringMedical ImagingMicroscopyAdvanced Imaging +7

Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis

Chudi Ndubaku, Terry D. Crawford, Huifen Chen, +21

ACS Medicinal Chemistry Letters

Ocular DiseaseMedicinal ChemistryAngiogenesisRetinaAdvanced Compound 13 +19

A zipper network model of the failure mechanics of extracellular matrices

Michael C. Ritter, Rajiv Jesudason, Arnab Majumdar, +5

Proceedings of the National Academy of Sciences

Tissue EngineeringBiophysical ModelingEngineeringCell AdhesionCytoskeleton +24

Differential effects of static and cyclic stretching during elastase digestion on the mechanical properties of extracellular matrices

Rajiv Jesudason, Lauren D. Black, Arnab Majumdar, +2

Journal of Applied Physiology

Tissue EngineeringMuscle FunctionEngineeringCyclic StretchMechanotransduction +21

MAP4K4 negatively regulates CD8 T cell–mediated antitumor and antiviral immunity

Emel Esen, Ismail Sergin, Rajiv Jesudason, +11

Science Immunology