A Structural Model of the Staphylococcus aureus ClfA–Fibrinogen Interaction Opens New Avenues for the Design of Anti-Staphylococcal Therapeutics

Vannakambadi K. Ganesh, Julián Rivera, Emanuel Smeds, +6

PLoS Pathogens

Large-scale inference of protein tissue origin in gram-positive sepsis plasma using quantitative targeted proteomics

Erik Malmström, Ola Kilsgård, Simon Hauri, +4

Nature Communications

Fibrinogen Is a Ligand for the Staphylococcus aureus Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMM) Bone Sialoprotein-binding Protein (Bbp)

Vanessa Vazquez, Xiaowen Liang, Jenny K. Horndahl, +4

Journal of Biological Chemistry

Biomimetic MaterialsProtein AssemblyMolecular BiologyBiomedical EngineeringAnalytical Ultracentrifugation +15

Heparan Sulfate Synthesized by Mouse Embryonic Stem Cells Deficient in NDST1 and NDST2 Is 6-O-Sulfated but Contains No N-Sulfate Groups

Katarina Holmborn, Johan Ledin, Emanuel Smeds, +3

Journal of Biological Chemistry

GlycobiologyPrior N-sulfationN-sulfate GroupsBiosynthesisTissue Development +14

Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia

Matthew J. Flick, Xinli Du, Joni M. Prasad, +5

Blood

Substrate specificities of mouse heparan sulphate glucosaminyl 6-O-sulphotransferases

Emanuel Smeds, Hiroko Habuchi, Anh-Tri Do, +5

Biochemical Journal

Molecular Characterization of the Interaction of Staphylococcal Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMM) ClfA and Fbl with Fibrinogen

Joan A. Geoghegan, Vannakambadi K. Ganesh, Emanuel Smeds, +3

Journal of Biological Chemistry

Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo

Johannes Westman, Praveen Papareddy, Madelene W. Dahlgren, +8

PLoS Pathogens

Microbial PathogensInnate Immune SystemImmunologyImmune RegulationPathology +21

Oligosaccharide Library-based Assessment of Heparan Sulfate 6-O-Sulfotransferase Substrate Specificity

Per Jemth, Emanuel Smeds, Anh-Tri Do, +4

Journal of Biological Chemistry

Heparan Sulfate BiosynthesisEnzyme SourceBiosynthesisBiotransformationLibrary-based Assessment +12

The role of extracellular vesicle fusion with target cells in triggering systemic inflammation

Praveen Papareddy, Ines Tapken, Keshia Kroh, +14

Nature Communications