Inhibition of Tumorigenicity and Metastasis of Human Melanoma Cells by Anti-Cathepsin L Single Chain Variable Fragment

Nathalie Rousselet, Lisa Mills, Didier Jean, +3

Cancer Research

The Role of Histidine 231 in Thermolysin-like Enzymes.

Ann Beaumont, Michael O’Donohue, Nathalie Paredes, +5

Journal of Biological Chemistry

New Dual Inhibitors of Neutral Endopeptidase and Angiotensin-Converting Enzyme: Rational Design, Bioavailability, and Pharmacological Responses in Experimental Hypertension

Marie‐Claude Fournié‐Zaluski, Pascale Coric, Serge Turcaud, +7

Journal of Medicinal Chemistry

HypertensionBioorganic ChemistryCardiovascular PharmacologyPharmacotherapyIc50 Nep +17

MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology

Florence Sonneville, Manon Ruffin, Christelle Coraux, +5

Nature Communications

FAM13A is a modifier gene of cystic fibrosis lung phenotype regulating rhoa activity, actin cytoskeleton dynamics and epithelial-mesenchymal transition

Harriet Corvol, Nathalie Rousselet, Kristin Thompson, +11

Journal of Cystic Fibrosis

FibrosisLung InflammationCytoskeleton DynamicsPathologyModifier Gene +7

Small RNA and transcriptome sequencing reveal the role of miR‐199a‐3p in inflammatory processes in cystic fibrosis airways

Pauline Bardin, Emmeline Marchal‐Duval, Florence Sonneville, +5

The Journal of Pathology

Expression of cathepsin L in human tumor cells is under the control of distinct regulatory mechanisms

Didier Jean, Nathalie Rousselet, Raymond Frade

Oncogene

Signal TransductionCathepsin LHuman Tumor CellsMedicinePathology +7

Down‐regulation of the expression of RB18A/MED1, a cofactor of transcription, triggers strong tumorigenic phenotype of human melanoma cells

Jean De La Croix Ndong, Didier Jean, Nathalie Rousselet, +1

International Journal of Cancer

Transcriptional RegulationMelanoma PhenotypeMedicineMelanomaGene Expression +11

Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: role of its 5′-untranslated region

Didier Jean, Nathalie Rousselet, Raymond Frade

Biochemical Journal

ImmunologyMolecular BiologyCysteine ProteaseCathepsin L ExpressionCellular Physiology +17

Intratumoral gene delivery of anti-cathepsin L single-chain variable fragment by lentiviral vector inhibits tumor progression induced by human melanoma cells

Raymond Frade, Nathalie Rousselet, Didier Jean

Cancer Gene Therapy

MedicineImmunologyHuman Melanoma CellsIntratumoral Gene DeliveryGene Vector +5