Jean‐Yves Thomas

Design, Synthesis, and Pharmacology of Novel 7-Substituted 3,4-Dihydro-2<i>H</i>-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of AMPA Receptors

Pierre Francotte, Pascal De Tullio, Eric Goffin et al. · Journal of Medicinal Chemistry · 2007 · 72 citations

Medicine, Neuroscience, Pharmacology +17

New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors

Pierre Francotte, Eric Goffin, Pierre Fraikin et al. · Journal of Medicinal Chemistry · 2010 · 60 citations

Medicine, Medicinal Chemistry, Pharmacology +15

DRUG FOCUS: S 18986: A Positive Allosteric Modulator of AMPA‐Type Glutamate Receptors Pharmacological Profile of a Novel Cognitive Enhancer

Katy Bernard, Laurence Danober, Jean‐Yves Thomas et al. · CNS Neuroscience & Therapeutics · 2010 · 35 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators

Pierre Francotte, Pascal De Tullio, Tchao Podona et al. · Bioorganic & Medicinal Chemistry · 2008 · 32 citations

Medicine, Medicinal Chemistry, Pharmacology +9

Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2<i>H</i>-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2<i>H</i>-1,2,4-benzothiadiazine 1,1-Dioxides

Pierre Francotte, Ann‒Beth Nørholm, Taru Deva et al. · Journal of Medicinal Chemistry · 2014 · 27 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17