Activation of the epithelial Na+ channel triggers prostaglandin E2 release and production required for embryo implantation

Ye Chun Ruan, Jinghui Guo, Xinmei Liu, +12

Nature Medicine

Developmental BiologyMolecular PhysiologySignal TransductionPhysiologyImplantation (Embryology) +9

Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney

Petra Šimić, Wondong Kim, Wen Zhou, +22

Journal of Clinical Investigation

Renal InflammationFgf23 RegulatorRenal FunctionBone Morphogenic ProteinFgf23 Synthesis +21

Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division

John Replogle, Wen Zhou, Adrianna E. Amaro, +9

Proceedings of the National Academy of Sciences

Cell Cycle DelaysCancer BiologyCellular PhysiologyTumor BiologyDrug Resistance +14

Urine Osmolality, Response to Tolvaptan, and Outcome in Autosomal Dominant Polycystic Kidney Disease: Results from the TEMPO 3:4 Trial

Olivier Devuyst, Arlene B. Chapman, Ron T. Gansevoort, +7

Journal of the American Society of Nephrology

DNA Intercalation Facilitates Efficient DNA-Targeted Covalent Binding of Phenanthriplatin

Ali A. Almaqwashi, Wen Zhou, M. Nabuan Naufer, +4

Journal of the American Chemical Society

Molecular BiologyDna-phenanthriplatin BindingChemical BiologyDna NanotechnologySingle Molecule Biophysics +14

Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis

Wen Zhou, Petra Šimić, Iris Y. Zhou, +12

Journal of Clinical Investigation

Cellular PhysiologyRenal FunctionKidney Tubule RemodelingKidney GlycolysisMineral Metabolism +17

Regulation of smooth muscle contractility by the epithelium in rat vas deferens: role of ATP‐induced release of PGE₂

Ye Chun Ruan, Zhe Wang, Jian Du, +8

The Journal of Physiology

Prognostic Enrichment Design in Clinical Trials for Autosomal Dominant Polycystic Kidney Disease: The TEMPO 3:4 Clinical Trial

María V. Irazabal, Jaime D. Blais, Ronald D. Perrone, +9

Kidney International Reports

Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints

Yi Wen Kong, Erik C. Dreaden, Sandra Morandell, +15

Nature Communications

Metabolite profiling of CKD progression in the chronic renal insufficiency cohort study

Donghai Wen, Zihe Zheng, Aditya Surapaneni, +23

JCI Insight

HypertensionPotential BiomarkersMetabolic SyndromeMetabolite ProfilingRenal Function +17