Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Lulu Sun, Cen Xie, Guang Wang, +25

Nature Medicine

ProbioticDysbiosisHealth SciencesMedicineMicrobiota +12

A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy

Qiyao Chai, Xudong Wang, Lihua Qiang, +13

Nature Communications

Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system

Jing Wang, Bingxi Li, Pupu Ge, +5

Nature Immunology

Pulmonary TuberculosisHost Ubiquitin SystemTuberculosis PreventionImmunologyPathogenesis +7

<i>M. tuberculosis</i> PknG manipulates host autophagy flux to promote pathogen intracellular survival

Pupu Ge, Zehui Lei, Yang Yu, +9

Autophagy

The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation

Jing Wang, Pupu Ge, Lihua Qiang, +9

Nature Communications

A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination

Lihua Qiang, Yong Zhang, Zehui Lei, +11

Nature Communications

The ubiquitin ligase TRIM27 functions as a host restriction factor antagonized by Mycobacterium tuberculosis PtpA during mycobacterial infection

Jing Wang, Jade L. L. Teng, Dongdong Zhao, +4

Scientific Reports

Genomic and transcriptomic analysis of NDM-1 Klebsiella pneumoniae in spaceflight reveal mechanisms underlying environmental adaptability

Jia Li, Fei Liu, Qi Wang, +7

Scientific Reports

<i>Mycobacterium tuberculosis</i> protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity

Jing Wang, Pupu Ge, Zehui Lei, +14

EMBO Reports

Pulmonary TuberculosisProtein FunctionPathogenesisImmunologyTuberculosis +7

Simulated microgravity suppresses MAPK pathway‐mediated innate immune response to bacterial infection and induces gut microbiota dysbiosis

Jing Wang, Conghui Han, Zhe Lü, +12

The FASEB Journal

DysbiosisMicrobial PathogensHost-microbe InteractionsInnate Immune SystemImmunology +16