Concepedia

Tomáš Otava

TO

7

Publications

281

Citations

7

H-Index

2021

Active since

Affiliations

Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry(Current)

University of Chemistry and Technology, Prague

Charles University

University of Toronto

Tomáš Otava is an author at Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry specializing in structural biology, natural sciences, and virology.

ORCID

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Publications per year

2021–2024

7

Publications

7

The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors

Tomáš Otava, Michal Šála, Fengling Li et al. · ACS Infectious Diseases · 2021 · 94 citations

Coronaviral RNA-methyltransferases: function, structure and inhibition

Radim Nencka, Jan Šilhán, Martin Klíma et al. · Nucleic Acids Research · 2021 · 67 citations · Full text

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Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase

Jan Šilhán, Martin Klíma, Tomáš Otava et al. · Nature Communications · 2023 · 50 citations · Full text

Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors

Milan Štefek, Dominika Chalupská, Karel Chalupský et al. · ACS Omega · 2023 · 28 citations · Full text

Inhibitors of mpox VP39 2′-O methyltransferase efficiently inhibit the monkeypox virus

Michala Zgarbová, Tomáš Otava, Jan Šilhán et al. · Antiviral Research · 2023 · 20 citations · Full text

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