Concepedia

Author

Tomáš Otava

Czech Academy of Sciences, Institute of Organic Chemistry and BiochemistryORCID

Also Known As

Tomas Otava, Tomáš Otava

13

Publications

294

Citations

7

H-Index

8

Concepts

All Affiliations

Czech Academy of Sciences, Institute of Organic Chemistry and BiochemistryUniversity of Chemistry and Technology, PragueCharles UniversityUniversity of Toronto
TO

About

Tomáš Otava is an author at Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry specializing in structural biology, natural sciences, and virology.

Top Concepts

#ConceptH-IndexPublicationsCitations

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Medicine

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Natural Sciences

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Biochemistry

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67

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Molecular Biology

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Structural Biology

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Tomáš Otava

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7

Publications

281

Citations

7

H-Index

YearCitations

The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors

Tomáš Otava, Michal Šála, Fengling Li,

ACS Infectious Diseases

2021

94

Coronaviral RNA-methyltransferases: function, structure and inhibition

Radim Nencka, Jan Šilhán, Martin Klíma,

Nucleic Acids Research

2021

67

Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase

Jan Šilhán, Martin Klíma, Tomáš Otava,

Nature Communications

2023

50

Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors

Milan Štefek, Dominika Chalupská, Karel Chalupský,

ACS Omega

2023

28

Inhibitors of mpox VP39 2′-O methyltransferase efficiently inhibit the monkeypox virus

Michala Zgarbová, Tomáš Otava, Jan Šilhán,

Antiviral Research

2023

20

Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy

Milan Dejmek, Andrea Brázdová, Tomáš Otava,

European Journal of Medicinal Chemistry

2023

11

Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5′-carboxamides

Hugo Kocek, Dominika Chalupská, Milan Dejmek,

RSC Medicinal Chemistry

2024

11

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