The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation

Susan L. Kloet, Matthew Makowski, H. Irem Baymaz, +6

Nature Structural & Molecular Biology

ChromatinStem-cell DifferentiationLineage PlasticityDevelopmental BiologyCell Lineage +10

Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency

Guido van Mierlo, René A. M. Dirks, Laura De Clerck, +14

Cell stem cell

ChromatinChromatin RemodelingEpigenetic ChangeGeneticsEpigenomics +5

p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models

Edward J. Grow, B. D. Weaver, Christina M. Smith, +11

Nature Genetics

Lineage PlasticityCell LineageDevelopmental BiologyCell SpecializationMedicine +7

Sall4 controls differentiation of pluripotent cells independently of the Nucleosome Remodelling and Deacetylation (NuRD) complex

Anzy Miller, Susan L. Kloet, Remco Loos, +4

Development

Insight into the Architecture of the NuRD Complex

Saad AlQarni, Andal Murthy, Wei Zhang, +15

Journal of Biological Chemistry

Architectural DesignNurd ComplexGeometryAlgebraic AnalysisComplex Geometry

The Nucleosome Remodeling and Deacetylase Complex NuRD Is Built from Preformed Catalytically Active Sub-modules

Wenjuan Zhang, Alice Aubert, J.M. Gomez de Segura, +20

Journal of Molecular Biology

Single-cell RNA sequencing in facioscapulohumeral muscular dystrophy disease etiology and development

Anita van den Heuvel, Ahmed Mahfouz, Susan L. Kloet, +5

Human Molecular Genetics

Fshd TranscriptomeEngineeringGeneticsTranscriptomics TechnologyMolecular Genetics +17

The Nucleosome Remodelling and Deacetylation complex suppresses transcriptional noise during lineage commitment

Thomas Burgold, M. Barber, Susan L. Kloet, +8

The EMBO Journal

GeneticsGenomic MechanismLineage CommitmentEpigeneticsTranscriptional Regulation +18

IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion

Fabian Kaiser, Iga Janowska, Roberta Menafra, +13

Blood

Lymphocyte DevelopmentAdaptive Immune SystemImmunologyImmune RegulationImmunologic Mechanism +18

Estrogen Receptor Pathway Activity Score to Predict Clinical Response or Resistance to Neoadjuvant Endocrine Therapy in Primary Breast Cancer

Márcia A. Inda, Erik J. Blok, Peter J.K. Kuppen, +15

Molecular Cancer Therapeutics