Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype

Brunangelo Falini, Cristina Mecucci, Enrico Tiacci, +19

New England Journal of Medicine

Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin

Ramiro Garzon, Michela Garofalo, Maria Paola Martelli, +15

Proceedings of the National Academy of Sciences

EngineeringMixed-phenotype Acute LeukemiaGeneticsEpigeneticsTumor Biology +16

Molecular remission in PML/RAR alpha-positive acute promyelocytic leukemia by combined all-trans retinoic acid and idarubicin (AIDA) therapy. Gruppo Italiano-Malattie Ematologiche Maligne dell'Adulto and Associazione Italiana di Ematologia ed Oncologia Pediatrica Cooperative Groups.

Franco Mandelli, Daniela Diverio, Giuseppe Avvisati, +20

PubMed

Epigenetic Silencing of the Myelopoiesis Regulator microRNA-223 by the AML1/ETO Oncoprotein

Francesco Fazi, Serena Racanicchi, Giuseppe Zardo, +9

Cancer Cell

Epigenetic SilencingChromatinMyelopoiesis Regulator Microrna-223MedicineNatural Sciences +10

Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance

Myriam Alcalay, Enrico Tiacci, Roberta Bergomas, +14

Blood

Prospective Minimal Residual Disease Monitoring to Predict Relapse of Acute Promyelocytic Leukemia and to Direct Pre-Emptive Arsenic Trioxide Therapy

David Grimwade, Jelena Jovanović, Robert K. Hills, +14

Journal of Clinical Oncology

Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation for adults younger than 61 years: results of the AIDA-2000 trial of the GIMEMA Group

Francesco Lo‐Coco, Giuseppe Avvisati, Marco Vignetti, +22

Blood

Early Detection of Relapse by Prospective Reverse Transcriptase-Polymerase Chain Reaction Analysis of the PML/RARα Fusion Gene in Patients With Acute Promyelocytic Leukemia Enrolled in the GIMEMA-AIEOP Multicenter “AIDA” Trial

Daniela Diverio, Vincenzo Rossi, Giuseppe Avvisati, +11

Blood

Quantitative assessment of minimal residual disease in acute myeloid leukemia carrying nucleophosmin (NPM1) gene mutations

Paolo Gorello, Giovanni Cazzaniga, Federica Alberti, +12

Leukemia

Hematological MalignancyChromatinMedicineGeneticsAcute Myeloid Leukemia +9

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.

Pier Paolo Pandolfi, Myriam Alcalay, M Fagioli, +7

The EMBO Journal

Hematological MalignancyGeneticsPathologyMolecular GeneticsGenomic Variability +7