NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, +107

Nature

Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma

Ana L. Gomes, Ana Teijeiro, Stefan Burén, +6

Cancer Cell

InflammationMetabolic Associated SteatohepatitisHepatologyMetabolic Associated Steatotic Liver DiseaseNonalcoholic Fatty Liver Disease +10

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Mohsen Malehmir, Dominik Pfister, Suchira Gallage, +64

Nature Medicine

HepatologyMedicineLiver PhysiologyPlatelet GpibαSubsequent Liver Cancer +7

PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis

Nabil Djouder, Roland Tuerk, Marianne Suter, +12

The EMBO Journal

Efficient LipolysisSignal TransductionBiochemistryProtein PhosphorylationLipid Synthesis

Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells

Aoife McGinley, Caroline E. Sutton, Sarah C. Edwards, +7

Immunity

InflammationCytokineAutoimmune DiseaseImmune DysregulationIl-1β-producing Myeloid Cells +13

Inhibition of De Novo NAD + Synthesis by Oncogenic URI Causes Liver Tumorigenesis through DNA Damage

Krishna Seshu Tummala, Ana L. Gomes, Mahmut Yilmaz, +9

Cancer Cell

Reductive StressDna DamageOncogenic AgentLiver PhysiologyMolecular Biology +5

Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells

Krishna Seshu Tummala, Marta Brandt, Ana Teijeiro, +4

Cell Reports

S6K1-Mediated Disassembly of Mitochondrial URI/PP1γ Complexes Activates a Negative Feedback Program that Counters S6K1 Survival Signaling

Nabil Djouder, Stefan Christian Metzler, Alexander Schmidt, +4

Molecular Cell

Signal TransductionMitochondrial FunctionMitochondrial DynamicNatural SciencesNegative Feedback Program +8

Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms

Stefan Burén, Ana L. Gomes, Ana Teijeiro, +8

Cancer Cell

Signal TransductionMolecular RegulationCell SignalingPhysiologyDiabetes +7

URI Is an Oncogene Amplified in Ovarian Cancer Cells and Is Required for Their Survival

Jean‐Philippe Theurillat, Stefan Christian Metzler, Nico Henzi, +9

Cancer Cell

UrologyOncogene AmplifiedOncogenic AgentMedicineCancer Biology +7