AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

Sean Caenepeel, Sean P. Brown, Brian Belmontes, +35

Cancer Discovery

Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development

Daqing Sun, Zhihong Li, Yosup Rew, +46

Journal of Medicinal Chemistry

The Pinene Path to Taxanes. 6. A Concise Stereocontrolled Synthesis of Taxol

Paul A. Wender, Neil F. Badham, Simon P. Conway, +12

Journal of the American Chemical Society

BiologyConcise Stereocontrolled SynthesisChemical EngineeringPinene PathEngineering +13

The Pinene Path to Taxanes. 5. Stereocontrolled Synthesis of a Versatile Taxane Precursor

Paul A. Wender, Neil F. Badham, Simon P. Conway, +19

Journal of the American Chemical Society

BiologyPinene PathEngineeringDonut IconNatural Sciences +10

A Potent Class of GPR40 Full Agonists Engages the EnteroInsular Axis to Promote Glucose Control in Rodents

Jian Luo, Gayathri Swaminath, Sean P. Brown, +15

PLoS ONE

Glucose ControlGpr40 Full AgonistsInsulin SignalingGastrointestinal Peptide HormoneMolecular Pharmacology +18

Identification and Pharmacological Characterization of Multiple Allosteric Binding Sites on the Free Fatty Acid 1 Receptor

Daniel C.-H. Lin, Qi Guo, Jian Luo, +12

Molecular Pharmacology

AMG 837: A Novel GPR40/FFA1 Agonist that Enhances Insulin Secretion and Lowers Glucose Levels in Rodents

Daniel C.-H. Lin, Jane Zhang, Run Zhuang, +16

PLoS ONE

Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1

Yumei Xiong, Gayathri Swaminath, Qiong Cao, +18

Molecular and Cellular Endocrinology

Molecular PhysiologySignal TransductionEndocrine MechanismG Protein-coupled ReceptorHormonal Receptor +8

Effects of peroxisome proliferator-activated receptor α/δ agonists on HDL-cholesterol in vervet monkeys

Jeanne M. Wallace, Margrit Schwarz, Peter Coward, +5

Journal of Lipid Research

Metabolic SyndromeBiochemistryCardiovascular DiseaseMedicinePhysiology +13

Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist

Sean P. Brown, Paul J. Dransfield, Marc Vimolratana, +15

ACS Medicinal Chemistry Letters

Partial Agonist 1Pancreatic IsletsBiochemistryFunctional SelectivityMedicine +10