Irmgard Hölker

Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis

Anna Kaczmarek, Svenja Schneider, Kathryn J. Swoboda et al. · The American Journal of Human Genetics · 2017 · 215 citations · Full text

Neuroregeneration, Spinal Cord Injury, Physiology +9

Mutations in BICD2, which Encodes a Golgin and Important Motor Adaptor, Cause Congenital Autosomal-Dominant Spinal Muscular Atrophy

Kornelia Neveling, Lilian A. Martinez-Carrera, Irmgard Hölker et al. · The American Journal of Human Genetics · 2013 · 173 citations · Full text

Mendelian Disorder, Genetic Disorder, Genetics +6

<i>In vitro</i> and <i>ex vivo</i> evaluation of second‐generation histone deacetylase inhibitors for the treatment of spinal muscular atrophy

Eric Hahnen, Ilker Y. Eyüpoglu, Lars Brichta et al. · Journal of Neurochemistry · 2006 · 149 citations

Histone Modifications, Chromatin, Histone Deacetylase +13

In vivo activation of <i>SMN</i> in spinal muscular atrophy carriers and patients treated with valproate

Lars Brichta, Irmgard Hölker, Karsten Haug et al. · Annals of Neurology · 2006 · 139 citations

LBH589 induces up to 10-fold SMN protein levels by several independent mechanisms and is effective even in cells from SMA patients non-responsive to valproate

Lutz Garbes, Irmgard Hölker, Raoul Heller et al. · Human Molecular Genetics · 2009 · 106 citations

Histone Modifications, Several Independent Mechanisms, Epigenetic Change +21