Jerome Michaux

Discovery and SAR of 5-(3-Chlorophenylamino)benzo[<i>c</i>][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Cancer

Fabrice Pierre, Peter Chua, Sean O’Brien et al. · Journal of Medicinal Chemistry · 2010 · 295 citations · Full text

Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics

Mustapha Haddach, Michael K. Schwaebe, Jerome Michaux et al. · ACS Medicinal Chemistry Letters · 2012 · 156 citations · Full text

Engineering, Rna Pol, Molecular Biology +17

Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer

Fabrice Pierre, Peter Chua, Sean O’Brien et al. · Molecular and Cellular Biochemistry · 2011 · 151 citations

Medicine, Cancer Growth, Immune Checkpoint Inhibitor +8

Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor

Mustapha Haddach, Jerome Michaux, Michael K. Schwaebe et al. · ACS Medicinal Chemistry Letters · 2011 · 84 citations · Full text

Pim Kinases, Pharmacotherapy, A Potent +18

Synthesis and SAR of inhibitors of protein kinase CK2: Novel tricyclic quinoline analogs

Mustapha Haddach, Fabrice Pierre, Collin F. Regan et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 16 citations · Full text

Medicinal Chemistry, Biochemistry, Protein Kinase Ck2 +7