Fabrizio Benedicenti

Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits Metachromatic Leukodystrophy

Alessandra Biffi, Eugenio Montini, Laura Lorioli et al. · Science · 2013 · 1.2K citations · Full text

Life Sciences, Genetics, Hematology +16

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

Eugenio Montini, Daniela Cesana, Manfred Schmidt et al. · Nature Biotechnology · 2006 · 705 citations

Medicine, Biotechnology, Oncology +14

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

Eugenio Montini, Daniela Cesana, Manfred Schmidt et al. · Journal of Clinical Investigation · 2009 · 573 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +16

Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial

Maria Sessa, Laura Lorioli, Francesca Fumagalli et al. · The Lancet · 2016 · 507 citations

Medicine, Hematology, Molecular Medicine +13

Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection

Alessandra Biffi, Cynthia C. Bartolomae, Daniela Cesana et al. · Blood · 2011 · 241 citations · Full text

Life Sciences, Pharmaceutical Biotechnology, Gene Therapy +11