Hepatic Krüppel-like factor 16 (KLF16) targets PPARα to improve steatohepatitis and insulin resistance

Nannan Sun, Chuangpeng Shen, Lei Zhang, +13

Gut

Ginsenoside Rg2 Ameliorates High-Fat Diet-Induced Metabolic Disease through SIRT1

Bo Cheng, Weihang Gao, Xiaojie Wu, +11

Journal of Agricultural and Food Chemistry

Lipid PeroxidationInsulin SignalingOxidative StressInflammationMetabolic Syndrome +14

Acute toxicity is a dose-limiting factor for intravenous polymyxin B: A safety and pharmacokinetic study in healthy Chinese subjects

Xiaofen Liu, Yuancheng Chen, Haijing Yang, +16

Journal of Infection

Intravenous Polymyxin BHealth SciencesHealthy Chinese SubjectsPharmacologyPoisoning +8

Safety and Clinical Pharmacokinetics of Nemonoxacin, a Novel Non-Fluorinated Quinolone, in Healthy Chinese Volunteers Following Single and Multiple Oral Doses

Beining Guo, Xiaojie Wu, Yingyuan Zhang, +4

Clinical Drug Investigation

MedicinePharmacotherapyAntimicrobial PharmacokineticsClinical PharmacokineticsNovel Non-fluorinated Quinolone +3

Development and validation of a UHPLC–MS/MS assay for colistin methanesulphonate (CMS) and colistin in human plasma and urine using weak-cation exchange solid-phase extraction

Miao Zhao, Xiaojie Wu, Yaxin Fan, +2

Journal of Pharmaceutical and Biomedical Analysis

Colistin MethanesulphonateSeparation ScienceMedicineUhplc–ms/ms AssayBioanalysis +12

Population Pharmacokinetics and Dosing Regimen Optimization of Meropenem in Cerebrospinal Fluid and Plasma in Patients with Meningitis after Neurosurgery

Cheng Lu, Yuyi Zhang, Mingyu Chen, +6

Antimicrobial Agents and Chemotherapy

Translational MedicineCsf SamplesCerebrospinal FluidPatient SafetyIntracranial Pressure +10

Selective method for the determination of cefdinir in human plasma using liquid chromatography electrospray ionization tandam mass spectrometry

Zhangjing Chen, Jing Zhang, Jicheng Yu, +3

Journal of Chromatography B

Analytical InstrumentationBiochemistryGas ChromatographyMedicineSelective Method +9

Claudin 18.2-targeting antibody–drug conjugate CMG901 in patients with advanced gastric or gastro-oesophageal junction cancer (KYM901): a multicentre, open-label, single-arm, phase 1 trial

Dan-Yun Ruan, Furong Liu, Xiao-Li Wei, +17

The Lancet Oncology

Gastrointestinal OncologyMedicineImmunologyPathologyAdvanced Gastric +5

Clinicopathologic significance of LAIR-1 expression in hepatocellular carcinoma

Xiaojie Wu, Leyan Zhang, Jiadi Zhou, +8

Current Problems in Cancer

HepatologyHepatocellular CarcinomaPathologyLiver CancerLair-1 Expression +3

Short-term Safety, Tolerability, and Pharmacokinetics of MRX-I, an Oxazolidinone Antibacterial Agent, in Healthy Chinese Subjects

Xiaojie Wu, Yunfei Li, Jing Zhang, +13

Clinical Therapeutics

Drug SafetyAntibioticsShort-term SafetyMedicineHealthy Chinese Subjects +7