An evaluation framework for new approach methodologies (NAMs) for human health safety assessment

Stanley T. Parish, Michael Aschner, Warren Casey, +10

Regulatory Toxicology and Pharmacology

Toxicity TestingEvaluation FrameworkSafety ScienceInjury PreventionRegulatory Safety Science +24

A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes

Hiroyuki Ando, Takashi Yoshinaga, Wataru Yamamoto, +16

Journal of Pharmacological and Toxicological Methods

Electrophysiological Characteristics of Human iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced Proarrhythmic Potential

Wataru Yamamoto, Keiichi Asakura, Hiroyuki Ando, +14

PLoS ONE

Cardiac MuscleHeart FailureEngineeringBiomedical EngineeringCardiovascular Function +17

A Role of TMEM16E Carrying a Scrambling Domain in Sperm Motility

Sayuri Gyobu, Haruhiko Miyata, Masahito Ikawa, +4

Molecular and Cellular Biology

TRIC-A Channels in Vascular Smooth Muscle Contribute to Blood Pressure Maintenance

Daiju Yamazaki, Yasuharu Tabara, Satomi Kita, +22

Cell Metabolism

HypertensionMolecular PhysiologyCardiovascular DiseaseVascular AdaptationVascular Pharmacology +10

Essential role of the TRIC-B channel in Ca2+ handling of alveolar epithelial cells and in perinatal lung maturation

Daiju Yamazaki, Shinji Komazaki, Hiroki Nakanishi, +6

Development

Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization

Chengzhu Zhao, Atsuhiko Ichimura, Nianchao Qian, +12

Science Signaling

Contribution of K_ir2 potassium channels to ATP-induced cell death in brain capillary endothelial cells and reconstructed HEK293 cell model

Daiju Yamazaki, Hiroaki Kito, Seiji Yamamoto, +4

American Journal of Physiology-Cell Physiology

Chlorpyrifos inhibits neural induction via Mfn1-mediated mitochondrial dysfunction in human induced pluripotent stem cells

Shigeru Yamada, Yusuke Kubo, Daiju Yamazaki, +2

Scientific Reports

Ca2+ Overload and Sarcoplasmic Reticulum Instability in tric-a Null Skeletal Muscle

Xiaoli Zhao, Daiju Yamazaki, Ki Ho Park, +8

Journal of Biological Chemistry