Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

Weiwei Yang, Yan Xia, Haitao Ji, +6

Nature

Nuclear Pkm2Transcriptional RegulationSignal TransductionSignaling PathwayCell Regulation +4

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

Weiwei Yang, Yan Xia, David H. Hawke, +7

Cell

Histone ModificationsChromatinTranscriptional RegulationCell RegulationChromatin Remodeling +13

Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis

Yajuan Zhang, Guanzhen Yu, Huiying Chu, +10

Molecular Cell

MedicineProtein PhosphorylationCellular BiochemistryCancer MetabolismCell Biology +2

Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2

Ji Liang, Ruixiu Cao, Xiongjun Wang, +10

Cell Research

Trimethylamine‐<i>N</i>‐oxide promotes brain aging and cognitive impairment in mice

Li Dang, Yilang Ke, Rui Zhan, +9

Aging Cell

AgingHost-microbe InteractionsGut MicrobiotaBiogerontologyOxidative Stress +15

Neutrophils Promote the Malignant Glioma Phenotype through S100A4

Ji Liang, Yuji Piao, Lindsay Holmes, +4

Clinical Cancer Research

PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis

Ji Liang, Ruixiu Cao, Yajuan Zhang, +6

Nature Communications

Acquired Resistance to Anti-VEGF Therapy in Glioblastoma Is Associated with a Mesenchymal Transition

Yuji Piao, Ji Liang, Lindsay Holmes, +3

Clinical Cancer Research

α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development

Xiongjun Wang, Ruilong Liu, Xiujuan Qu, +11

Molecular Cell

Neuro-oncologyMedicineImmunologyBrain Tumor DevelopmentMetabolic Regulation +8

TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-Butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice

Mingming Zhao, Lin Zhao, Xuelian Xiong, +15

Gastroenterology

InflammationIntestinal MicrobesHepatologyHost-microbe InteractionsMedicine +12