Impact of Intestinal Microbiota on Intestinal Luminal Metabolome

Mitsuharu Matsumoto, Ryoko Kibe, Takushi Ooga, +5

Scientific Reports

DysbiosisHost-microbe InteractionsGastroenterologyGf MiceMetabolomic Profiling +14

Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice

Ryoko Kibe, Shin Kurihara, Yumi Sakai, +10

Scientific Reports

Cerebral Low-Molecular Metabolites Influenced by Intestinal Microbiota: A Pilot Study

Mitsuharu Matsumoto, Ryoko Kibe, Takushi Ooga, +4

Frontiers in Systems Neuroscience

Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidaemia

Takushi Ooga, Hajime Sato, Atsushi Nagashima, +4

Molecular BioSystems

GeneticsLipid PeroxidationMetabolomic ProfilingHyperlipidemiaOxidative Stress +19

Intestinal luminal putrescine is produced by collective biosynthetic pathways of the commensal microbiome

Atsuo Nakamura, Takushi Ooga, Mitsuharu Matsumoto

Gut Microbes

DysbiosisHost-microbe InteractionsDigestive TractProbioticIntestinal Luminal Putrescine +20

Colonic Absorption of Low-Molecular-Weight Metabolites Influenced by the Intestinal Microbiome: A Pilot Study

Mitsuharu Matsumoto, Takushi Ooga, Ryoko Kibe, +3

PLoS ONE

DysbiosisMembrane Transport SystemMetabolomic ProfilingDigestive TractLow-molecular-weight Metabolites Influenced +18

Degradation of ppGpp by Nudix Pyrophosphatase Modulates the Transition of Growth Phase in the Bacterium Thermus thermophilus

Takushi Ooga, Yoshiaki Ohashi, Seiki Kuramitsu, +4

Journal of Biological Chemistry

Structural Insights into the Thermus thermophilus ADP-ribose Pyrophosphatase Mechanism via Crystal Structures with the Bound Substrate and Metal

S. Yoshiba, Takushi Ooga, Noriko Nakagawa, +5

Journal of Biological Chemistry

Crystal StructureAdp-ribose PyrophosphataseMolecular BiologyRedox BiologyProtein X-ray Crystallography +14

Quantification of folate metabolism using transient metabolic flux analysis

Philip M. Tedeschi, Nadine Johnson-Farley, Hongxia Lin, +6

Cancer & Metabolism

Molecular Mechanism of the <i>Thermus thermophilus</i> ADP-Ribose Pyrophosphatase from Mutational and Kinetic Studies

Takushi Ooga, Sachico Yoshiba, Noriko Nakagawa, +2

Biochemistry