A clinical drug library screen identifies astemizole as an antimalarial agent

Curtis R. Chong, Xiaochun Chen, Lirong Shi, +2

Nature Chemical Biology

Antimalarial AgentPharmacological StudyAntiparasitic AgentMedicineClinical Pharmacology +5

Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics

Kristian E. Swearingen, Scott E. Lindner, Lirong Shi, +8

PLoS Pathogens

MalariaGlycobiologyBiological Mass SpectrometryMolecular BiologyImmunology +23

Haemoproteus and Schistosoma synthesize heme polymers similar to Plasmodium hemozoin and β-hematin

Mary M. Chen, Lirong Shi, David Sullivan

Molecular and Biochemical Parasitology

BiochemistryNatural SciencesMalariaHematologyMolecular Biology +7

Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages

Evelien M. Bunnik, Kate B. Cook, Nelle Varoquaux, +15

Nature Communications

Inhibitors of <i>Plasmodium falciparum</i> methionine aminopeptidase 1b possess antimalarial activity

Xiaochun Chen, Curtis R. Chong, Lirong Shi, +3

Proceedings of the National Academy of Sciences

Medicinal ChemistryDrug TargetBiochemistryAntiparasitic AgentMedicine +13

Proteolytic Cleavage of the<i>Plasmodium falciparum</i>Circumsporozoite Protein Is a Target of Protective Antibodies

Diego A. Espinosa, Gabriel M. Gutierrez, Maricarmen Rojas-López, +5

The Journal of Infectious Diseases

MalariaImmunologyMolecular BiologyPathologyImmunotherapy +14

Reversible Conformational Change in the Plasmodium falciparum Circumsporozoite Protein Masks Its Adhesion Domains

Raúl Herrera, Charles Anderson, Krishan Kumar, +22

Infection and Immunity

Copper pathways in <i>Plasmodium falciparum</i> infected erythrocytes indicate an efflux role for the copper P-ATPase

Dominique Rasoloson, Lirong Shi, Curtis R. Chong, +2

Biochemical Journal

Efflux RoleIron MetabolismMalariaMolecular BiologyChemical Biology +17

Short-Term Malaria Reduction by Single-Dose Azithromycin during Mass Drug Administration for Trachoma, Tanzania

Stephen E. Schachterle, George Mtove, Joshua Levens, +7

Emerging infectious diseases

Trachoma WorldwidePlasmodium Falciparum InfectionsAntibioticsMalariaPharmacology +11

Zinc Protoporphyrin IX Binds Heme Crystals to Inhibit the Process of Crystallization in Plasmodium falciparum

Jayasree K. Iyer, Lirong Shi, Anuraj H. Shankar, +1

Molecular Medicine