Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9

Brian J. DeBosch, Oliver Kluth, Hideji Fujiwara, +2

Nature Communications

Metabolic SyndromeUrologyMetabolic DisorderMetabolic DiseasePhysiology +6

Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure

Oliver Kluth, Farshad Mirhashemi, Stephan Scherneck, +5

Diabetologia

Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation

Oliver Kluth, Daniela Matzke, Anne Kamitz, +9

PLoS Genetics

Systems BiologyDevelopmental BiologyMolecular PathwayMedicineDiabetes +11

Estrogen Deficiency Aggravates Insulin Resistance and Induces β-Cell Loss and Diabetes in Female New Zealand Obese Mice

Heike Vogel, Farshad Mirhashemi, Beate Liehl, +5

Hormone and Metabolic Research

NutritionMetabolic DisorderGynecologyCaloric RestrictionGlucose Tolerance +20

Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

Oliver Kluth, Mandy Stadion, Pascal Gottmann, +9

Cell Reports

Differential Transcriptome Analysis of Diabetes-Resistant and -Sensitive Mouse Islets Reveals Significant Overlap With Human Diabetes Susceptibility Genes

Oliver Kluth, Daniela Matzke, G Schulze, +3

Diabetes

GLP-1–oestrogen attenuates hyperphagia and protects from beta cell failure in diabetes-prone New Zealand obese (NZO) mice

Robert W. Schwenk, Christian Baumeier, Brian Finan, +6

Diabetologia

Diet Dependence of Diabetes in the New Zealand Obese (NZO) Mouse: Total Fat, But not Fat Quality or Sucrose Accelerates and Aggravates Diabetes

Farshad Mirhashemi, Stephan Scherneck, Oliver Kluth, +6

Experimental and Clinical Endocrinology & Diabetes

Distinct functions of the dual leucine zipper kinase depending on its subcellular localization

Manuel Wallbach, Jorge Duque Escobar, Rohollah Babaeikelishomi, +9

Cellular Signalling

Signal TransductionCell RegulationNatural SciencesReceptor Tyrosine KinaseAutophagy +10

Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms

Madhura Panse, Oliver Kluth, Estela Lorza‐Gil, +6

PLoS ONE

Distinct MechanismsCell DeathInsulin SignalingOxidative StressMetabolic Syndrome +15