Matthew M. Zrada

Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca²⁺Channel Antagonist

William D. Shipe, James C. Barrow, Zhi-Qiang Yang et al. · Journal of Medicinal Chemistry · 2008 · 133 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of 1,4-Substituted Piperidines as Potent and Selective Inhibitors of T-Type Calcium Channels

Zhiqiang Yang, James C. Barrow, William D. Shipe et al. · Journal of Medicinal Chemistry · 2008 · 94 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Kinesin spindle protein (KSP) inhibitors. Part V: Discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by β-fluorination to overcome cellular efflux by P-glycoprotein

Christopher D. Cox, Michael J. Breslin, David B. Whitman et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 53 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines

Laura C. Meurer, Richard L. Tolman, Edward W. Chapin et al. · Journal of Medicinal Chemistry · 1992 · 44 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

The anesthetized guinea pig: An effective early cardiovascular derisking and lead optimization model

Pierre Morissette, Masahiro Nishida, Elena S. Trepakova et al. · Journal of Pharmacological and Toxicological Methods · 2013 · 38 citations

Medicine, Cardiology, Physiology +9